Discovery of Endogenous Retroviruses in Human Blood Stem Cells

Scientists have discovered endogenous retroviruses (ERVs) in human blood stem cells. This discovery could transform our understanding of the human genome and diseases such as blood cancer.
 
According to MedicalXpress, researchers from Tufts University and Boston Children’s Hospital Medical Center have identified DNA fragments of endogenous retroviruses in these cells. These retroviruses infected our ancestors’ genomes millions of years ago and are now part of our DNA.
 
While most endogenous retroviruses are inactive, some can influence the activity of neighboring genes. This research shows that some of these retroviruses are specifically active in blood stem cells and may play a role in processes such as hematopoiesis (blood cell production).
 
Interestingly, the activity pattern of endogenous retroviruses varies among different individuals and can be influenced by environmental factors and diseases such as blood cancer. This finding could lead to the development of novel treatments for blood cancer and other blood disorders.
 
Using advanced genome sequencing technologies, scientists successfully identified these active endogenous retroviruses in blood stem cells. This research highlights the importance of studying endogenous retroviruses for better understanding human health and disease, potentially paving the way for future research in this field. Indeed, this discovery opens a new window into understanding the complexities of the human genome and its relationship with diseases.
 

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